Does immunosuppression affect the course of septic shock?

Although sepsis was recognized first by Hippocrates (c.a. 460–370 BC) more than 2,000 years ago, many components of this complex clinical picture yet await to be established due to the unmet need to overcome its untoward consequences such as mortality, morbidity and increased health care use costs (1). Today, excluding the data from the cardiac intensive care units, sepsis is the major reason for mortality at intensive care units (ICU), with sepsis and septic shock accounting for approximately 30–50% of ICU-related deaths (2,3)