Recombinant Newcastle disease virus expressing human IFN-λ1 (rL-hIFN-λ1) inhibits lung cancer migration through repolarizating macrophage from M2 to M1 phenotype

Lung cancer is a serious threat to human health and has been the most common cause of cancer-related death worldwide. The 5-year survival rate of lung cancer patients diagnosed at a distant stage is as low as 5% (1). The low survival rate of lung cancer patients is much closely related with the uncontrolled proliferation and metastasis of cells within the lung (2). Radiotherapy and chemotherapy can improve the 5-year survival rate of patients with lung cancer to a certain extent, but the effect is limited. Immune escape or immune tolerance seriously affects the therapeutic effect of lung cancer. In recent years, tumor immunotherapy has gradually entered people's field of vision, which is another great breakthrough in the development of science and technology, and has become a new hot spot in tumor treatment