The effects of HBXIP on the biological functions of tongue squamous cell carcinoma cells and correlation with PI3K/Akt

Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors in the head and neck, accounting for 3% of all malignant tumors (1). It has high malignancy, easily develops early metastasis; its overall 5-year survival rate ranges between 45–55% (2), which has hardly changed during the past 30 years (3,4). Surgical treatment predominates, and the available adjuvant therapies include radiotherapy and chemotherapy. Although the surgical techniques have remained unchanged for many years, every doctor strives to improve the quality of surgery. A new study found that an ultrasonic coagulation device was effective in providing safe and adequate margins in operations for carcinoma tongue (5). Due to the lack of highly effective treatment options, most TSCC patients experience recurrence and metastasis after operation and those in the advanced stage have lower survival