MicroRNA expression integrated analysis and identification of novel biomarkers in small cell lung cancer: a meta-analysis

Recent studies showed that lung cancer was still the most common tumor in China and even the world, accounting for 18.4% of all tumor deaths (1). Small cell lung cancer (SCLC) is a subtype of lung cancer, as accounting for 10% to 15% in lung cancer. As the difficulty in early diagnosis, short treatment time window and lacking specific therapeutic regimens for SCLC, the five-year survival rate of the patient was only about 5% (2,3). Therefore, the key points to improving SCLC survival is deeply understand the tumorigenesis mechanism and exploration of more effective and improved treatment methods