Utility of thrombophilia testing in patients with venous thrombo-embolism

Thrombophilia is an acquired or congenital abnormality of haemostasis predisposing to thrombosis. A thrombophilia screen panel in Queensland public hospitals includes protein C and protein S levels, antithrombin III level, lupus anticoagulant, activated protein C resistance (factor 5 Leiden mutation tested if positive or if specifically requested) and prothrombin gene mutation (PG202A). Antiphospholipid antibodies (anti-cardiolipin antibody and beta 2 glycoprotein antibody) require specific requests