Quercetin and Vincristine Potential of Methanolic Extract from Arjun Tree

Polyphenolic compounds like Gallic acid, ethyl gallate, quercetin, kempferol, proanthrocyanidin, EPGA, resveratrol have been familiar as neutraceuticals for possessing anti-oxidant, anti-inflammatory, and anti-cancer activities. Arjun Tree (Terminalia Arjuna) is a very ancient plant which contains many reported polyphenolic compounds having antifungal, cardioprotective, anti-mutagenic, anti-inflammatory, anti-allergic, anti-bacterial, cytotoxic, anti-oxidant properties. Here we reported methanolic extract of Terminalia arjuna, which neutralized 50% (IC50) of free radicals at a concentration of 3.29 ？？g/ml, while the standard neutralizes 50% (IC50) of free radical at a concentration of 1.92 ？？g/ml. The total phenolic content was 449.8 ？？g/ml of dry weight of extract, expressed as gallic acid equivalents. The total flavonoid concentration was 206.91？？g/ml, expressed as quercetin equivalents. In the brine shrimp lethality test, LC50 obtained from the line slope were 0.419 and 12.5, which is greater than that of 0.781 ？？g/ml for standard vincristine sulphate, aqueous fraction