Molecular Insight Into Pathogenesis of Potentially Malignant Disorders of Oral Cavity

Early detection can decrease both morbidity and mortality associated with this neoplasm. However, screening for potentially malignant disease is typically confounded by difficulty in discriminating between reactive/inflammatory lesions vs those lesions that are premalignant in nature. Selected markers for cell proliferation, adhesion, apoptosis and lymphocytic infiltration were analysed by immunohistochemistry in addition to static cytometry for DNA content. In the present review, we have discussed the molecular pathogenesis of Oral lichen planus, oral sub mucous fibrosis and Leukoplakia