Frequency of HLA-B27 gene among patients with ankylosing spondylitis and its consequences on clinical manifestation

Background: Ankylosing spondylitis is an inflammatory disease and leading case of back pain worldwide. It is thought that the gene human leukocyte antigen-B27 (HLA-B27) provides a strong tendency in people to develop ankylosing spondylitis. This study was designed to evaluate the frequency of HLA-B27 among patients with ankylosing spondylitis and clinical manifestation among the HLA-B27 positive and negative patients