VATER/VACTERL Association in Palestinian Children: A Case Report

VACTERL/VATER association is typically defined by the presence of at least three of the following congenital malformations: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities. This finding is supported by evidence linking all of the human disease genes for the VATER/ VACTERL association identified to date, namely, FGF8, FOXF1, HOXD13, LPP, TRAP1, and ZIC3, with renal malformations. VATER association was first described in 1972 by Quan and Smith. We present here a 75 days male boy with cardiac (VSD, PDA), esophageal atresia, anal abnormalities (sacral dimple), and genitourinary (hypospadias and communicating hydrocele). Others abnormalities were detected ear deformity, sacral dimple and 13 pairs of ribs