Serum Wnt5a Level is Associated with In-Stent Restenosis in PCI Patients

Objective: To explore the association between serum Wnt5a level and ISR, and to assess the possibility of Wnt5a to be a predictor of ISR. Methods: 184 bare metal stent (BMS) implanted patients were enrolled in this case-control study. According to coronary angiography results, all patients were divided into 2 groups: in-stent restenosis (ISR) group and non-ISR group. Serum Wnt5a levels were determined using enzyme-linked immune sorbent assay (ELISA). Results: Serum Wnt5a levels were higher in ISR group than those in non-ISR group, and were associated with the Gensini score. ISR rate was the highest in the upper tertile of Wnt5a. Multivariate logistic regression indicated that Wnt5a was an independent risk factor of ISR. For diagnosing ISR, the area under ROC curve was 0.817. The cutoff value of Wnt5a diagnosing ISR was 25.83ng/L, with the specificity of 60.68% and sensitivity of 89.55%. Conclusion: Serum Wnt5a levels is associated with ISR in PCI patients with BMS implantation. Wnt5a is an independent risk factor of ISR, and may act as a biomarker for diagnosing ISR in BMS implanted patients. Keywords: WNT5A; In-Stent Restenosis; Percutaneous coronary intervention; Bare metal stent