Ok-432 (Picibanil) In the Treatment of Ranulas

OK-432 is used as a chemotherapeutic agent in the treatment of cancer. Since 1987, however, it has been successfully used as a sclerotherapy agent in the treatment of cystic pathologies. A cystic malformation, known as ranula, is very common in the head and neck region. For this reason, sclerotherapy with OK-432 started to be used in the treatment of ranulas in the 1990s. A literature review of the use of OK-432 in simple, plunging, and parapharyngeal extended ranulas was undertaken with a focus on case reports and published research articles. The successful use of OK-432 in treatments and a discussion of outcomes and complications are discussed in addition to the advantages and disadvantages of OK-432 in ranula treatment. Keywords: OK-432; Ranula; Sclerotherap