New clinical trial rules: Academic trials and tribulations

Academic trials or investigator-initiated studies (IIS) are clinical studies conceived, planned, and managed by individual physician–researchers or an institution or a group of collaborative clinical researchers or institutions.[1,2] IIS include a wide range of studies – clinical trials of new drugs and real-world prospective or retrospective studies. IIS can help physicians in repurposing of drugs and in investigating health research questions relevant to their practice.[1] Data from real-world setting, which are applicable to population studied, can help in developing hospital/state/country-specific health guidelines and policies.[1