Evidence for circadian rhythm disruption in chronic rhinosinusitis

Circadian rhythms are the physiological processes of the human body that cycle every 24 hours. They are controlled by multiple endogenous and exogenous factors. When disrupted, they have significant metabolic, psychologic and sleep-related consequences. Patients with chronic rhinosinusitis(CRS) have increased sleep disruption; however circadian rhythms have never been investigated in this condition.