Common Variable Immunodeficiency with Angiosarcoma Associated with Hyperammonia Secondary to High Dose IVIG Infusion

Common Variable Immunodeficiency (CVID) is the most common, symptomatic immunodeficiency, marked by humoral deficiency and recurrent respiratory tract infections. Its management may involve intravenous immune globulin (IVIG), which includes a spectrum of adverse effects ranging from headaches to anaphylaxis or stroke. We report a 78 year old patient diagnosed with CVID and a liver angiosarcoma who developed hyperammonemia secondary to high dose IVIG.