In vitro Hypoallergenicity of Peanut Protein-Blueberry Polyphenol Aggregate Particles

The effector phase of the peanut (PN) allergic reaction involves crosslinking of PN allergen epitopes with PN-specific IgE located on mast cell and basophil surfaces causing them to degranulate and to release inflammatory compounds. Plant-derived polyphenolic compounds are able to bind to proteins. In this study, stable aggregate particles comprised of PN proteins and blueberry pomace polyphenols were investigated for their allergen response potential by binding to IgE in vitro.