Down-Regulated the Expression of Wdpcp Could Interrupt the Ciliogenesis in CRS

Cilia loss is one of the significant morphologic changes in sinonasal mucosa from patients with chronic rhinosinusitis (CRS). However, the mechanism for poor ciliation is still unclear.We sought to find out the role of WDPCP, a key factor for ciliogenesis in recent researches, in human sinonasal epithelia cells cilia loss from patients with CRS.