A Phenotypically Distinct Subset of Eosinophils is Recovered with Intestinal Intraepithelial Leukocytes

In health, intestinal eosinophils contribute to mucosal immunity. In disease, eosinophils are associated with GI disorders such as food allergies and eosinophilic gastrointestinal diseases (EGIDs). However, the phenotype and functions of intestinal eosinophils in health or disease are poorly understood. This study assessed the phenotype, in situ localization, and capacity for in vivo antigen acquisition of intestinal eosinophils from na？ve and allergic mice.