Effect of prenatal supplementation of mothers with Lactobacillus johnsonii on offspring microbiome and RSV immunity

The development of the immune system before and after birth may be altered by several extrinsic and intrinsic factors that could lead to severe disease predisposition in children who do not exhibit any known risk factor. Recently, the role of the microbiome and resulting metabolites have been an area of intense study in the development of lung disease, including viral infection and asthma. Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by two years old, and is the leading cause of hospitalization of infants worldwide.