Drug allergy testing and oral challenge test protocol with metronidazole

Metronidazole is the representative of nitroimidazoles the only class of medicines that is used for treatment of Trichomonas vaginalis and also a drug of choice in other infections: amebiasis; giardiasis; anaerobic bacterial and treponemal infections. Types I, II, and IV hypersensitivity reactions to metronidazole have been reported in the literature. Development of comprehensive protocol with validation of non-irritant concentrations for skin testing and intradermal testing was an unmet need that we addressed in our centre.