Reply to Kovacs et al.: Concerning acute inflammatory response following focused ultrasound and microbubbles in the brain

We thank Kovacs et al. for their editorial [15] on our recent publication [1] regarding the influence of microbubble (MB) dose on acute inflammatory response (AIR) following focused ultrasound (FUS)-induced increases in blood-brain barrier (BBB) permeability. We wish to address key points of disparity in interpretations of the data presented by us and in a previous report from Kovacs et al [2].