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Theranostics 2018
Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor modelDOI: 10.7150/thno.26706 Keywords: remote loading, pH-gradient liposomes, transmembrane ammonium sulfate, iodinated imaging agents, I-124, PET imaging Abstract: Long circulating liposomes entrapping iodinated and radioiodinated compounds offer a highly versatile theranostic platform. Here we report a new methodology for efficient and high-yield loading of such compounds into liposomes, enabling CT/SPECT/PET imaging and 131I-radiotherapy.
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