Preoperative Serum and Intra-platelet Serotonin in Prognosis: Useful or Useless?

We read the recent Journal of Cancer article published by Aryal et al with great interest [1]. The author demonstrated that lower serum and intra-platelet (IP) 5-HT were closely related with higher recurrence rate after four weeks of operation. Additionally, serum and IP 5-HT could be used as the independent factors to predict the recurrence of hepatocellular carcinoma. However, the preoperative serum and IP 5-HT did not affect the recurrence in their study. The serum and IP 5-HT were even higher in non-recurrence patients before operation.