卵巢癌多药耐药相关基因的生物信息学分析
DOI: 10.3971/j.issn.1000-8578.2016.06.012
Keywords: 卵巢癌,多药耐药,基因,生物信息学分析,筛选与挖掘,Effects of Silencing B7-H3 Gene on Invasion of Human Hepatocellular Carcinoma Cells,Effect of PTTG1 Expression on Invasion and Migration of Colon Cancer Cell SW480 and Its Possible Mechanism,Current Research Status of NF-kappa B Related Molecular Pathway in Diffuse Large B Cell Lymphoma,Effect of CGB5 on Human Epithelial Ovarian Cancer Cell Line OVCAR-3 in Vasculogenic Mimicry Formation,UGCG is Involved in Oxaliplatin Resistance Mechanism of Human Colon Cancer Through Regulating MDR1/P-gp Expression,Prognostic Significance of COX-2, NF-κB, WT-1 and PTEN Expression in Malignant Peritoneal Mesothelioma,Research Progress of circRNAs in Cancer,Immune Killing Effect of Silencing TIPE2 Expression on T Lymphocytes Against Lung Adenocarcinoma Cells LA795,Predictive Factors for Customizing Chemotherapy on Advanced Lung Adenocarcinoma,Expressions of MACC1 and c-Met Proteins in Lung Adenocarcinoma and Their Correlation with Postoperative Recurrence,Screening of Genes Involved in Hepatoma Cells SMMC-7721 Stress Response Induced by Different Stressors,Value of 21-gene Assay in Treatment Decisions for Hormone Receptor-positive Nodepositive Early Breast Cancer,miR-143/145 Cluster Regulate Multi-drug Resistance of Small Cell Lung Cancer,Clinical Investigation on Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy on Patients with Peritoneal Carcinomatosis from Epithelial Ovarian Cancer,Effect of AT Motif Binding Factor 1 on Proliferation and Invasion of Colorectal Carcinoma Cell Line LOVO
Abstract:
摘要 目的 筛选与挖掘卵巢癌多药耐药相关基因及其生物信息。方法 基于GSE41499、GSE33482、GSE15372和GSE28739等4套来源不同的卵巢癌化疗耐药与敏感基因芯片表达谱数据集， 综合运用差异基因表达分析、基因通路富集分析和文本挖掘等生物信息学方法预测卵巢癌多药耐药相关基因及通路。结果 MAPK信号通路、泛素介导的蛋白质水解、轴突导向、焦点粘连、神经营养素信号通路、癌症通路、肾细胞癌、柠檬酸循环、类萜骨干生物合成、错配修复和亨廷顿氏舞蹈病等11条基因通路是出现频率相对较高的显著性上调通路（P<0.05），甘油脂、戊醣酸途径、果糖和甘露糖代谢、谷胱甘肽代谢、蛋白酶体、p53信号通路和溶酶体等7条基因通路是出现频率相对较高的显著性下调通路（P<0.05）；进一步的文本挖掘发现，ACO1、BDNF、CXCR4、HMGCR和NRP1等5个上调表达基因（P<0.05）和CDKN2C、FAS和SKP2等3个下调表达基因（P<0.05）可能与卵巢癌多药耐药形成相关。结论 卵巢癌多药耐药机制的形成可能涉及到多种不同的通路和基因，其中ACO1、BDNF、CXCR4、HMGCR、NRP1、CDKN2C、FAS和SKP2等基因可能在其中发挥着关键作用，后续研究将对其进行实验和临床双重验证
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