单域抗体在肿瘤分子影像学中的研究进展
DOI: 10.3971/j.issn.1000-8578.2019.18.0473
Keywords: 单克隆抗体,单域抗体,分子影像,肿瘤靶向,Research Progress of PD-1/PD-L1 Targeted Radionuclide Molecular Probes in Tumor Immunotherapy,Progress in Mesothelin as Target for Cancer Specific Radionuclide Imaging,Comment on Prospect of Optical Molecular Imaging in Oncological Surgery,Progress of Molecular Imaging-guided Tumor Immunotherapy,Research Progress of FGFR4 Targeted Anti-tumor Drug,Molecular Classification of Common Solid Cancers,Progress in Adhesion Molecule CD24 in Ovarian Cancer,Clinical Study of Bevacizumab Combined with FOLFIRI Regimen in Treatment of Advanced Colorectal Cancer,Experimental on Antibody Targeting Liver Cancer Stem Cell Treatment,Experimental Research on Radioimmunotherapy of 131I-labeled AntiCD20 Monoclonal Antibody to Nude Mice Xenografted Tumor,Preparation and Identification of Monoclonal Antibodies Against Human Stathmin,Characteristic Analysis of Immunological Classification of 139 Examples Acute Myeloid Leukemia,Construction of Anaerobic Infant Bifidobacterial Mediated pTRKH2-PsT/CD and pTRKH2-PsT/UPRT Dual Suicide System for Tumortargetting Gene Therapy,Radioimmunoimaging of Anti-CD20 Monoclonal Antibody Labeled with 131I in Nude Mice Xenografted with Raji Cells Tumor in Vivo,A Tumor-targeted Vector for Interleukin-12 Gene Therapy to Enhance the Anti-osteosarcoma Immunity in Nude Mouse
Abstract:
摘要 单域抗体（single-domain antibody, sdAb）是一种从骆驼科动物血清中提取的仅具有重链的抗体的可变区。单域抗体具有易表达、水溶性好、稳定性强、免疫原性弱等特点。与常规抗体相比，单域抗体在组织中的穿透率更高，并且能够通过肾脏被快速清除，使其能被理想地应用于各种生物技术和肿瘤临床治疗。单价sdAbs可以与放射性同位素、荧光染料、生物素、磁珠、亲和基质等化学物质偶联形成复合型分子偶联的sdAbs，可用于多种模式的在体肿瘤成像，在基础研究、探针开发等领域有着广阔的应用前景。本文就单域抗体的分子特征和其在肿瘤分子影像学中的应用进行综述
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