新辅助与辅助膀胱热灌注化疗治疗高危非肌层浸润性膀胱癌的疗效对比
DOI: 10.3971/j.issn.1000-8578.2019.18.1176
Keywords: An Update,Report on Six Cases of Invasive Bladder Cancer Treated with Natural Orifice Specimen Extraction Combined with Sigmoid Colon in situ Neo-bladder Surgery,Clinical Outcomes of Neoadjuvant Versus Adjuvant Chemotherapy on Muscle-invasive Bladder Cancer,Relationship of Integrinβ1 and CARMA-3 Protein Expressions with Recurrence of Bladder Cancer After Transurethral Resection of Bladder Tumor,Correlation of FoxO3 Gene with Clinicopathological Features and Prognosis of Bladder Cancer Patients,Clinical Efficacy of Gemcitabine plus S-1 on Refractory Nasopharyngeal Carcinoma Patients and Their Influence on Immune Function,Research Progress of Novel Endoscopic Imaging Technology for Bladder Cancer Diagnosis,Clinical Efficacy and Toxicities of Oxaliplatin plus S-1(SOX) and Gemcitabine plus Cisplatin (GP) Regimens on Advanced Triple-negative Breast Cancer Patients,Clinical Evaluation of Bladder-sparing Surgery Combined with Internal Iliac Artery Chemotherapy for Muscle-invasive Bladder Cancer Patients,Value of Circulating Tumor Cells in Early Monitoring of Bladder Cancer Micrometastases,Comparison Between Concurrent Chemoradiotherapy plus Sequential Chemotherapy and Sequential Chemoradiotherapy Alone on Locally Advanced Non-small Cell Lung Cancer Patients,Clinical Significance of Embolization on Quality of Life of Elderly Patients with Bladder Hemorrhage,Molecular Mechanism of RhoGDI2 Inhibiting Metastasis of Bladder Cancer,Recent Progress on Isolating Bladder Cancer Stem Cells
Abstract:
摘要 目的 探讨经尿道膀胱肿瘤电切术（TURBT）术前新辅助膀胱热灌注化疗对比术后辅助膀胱热灌注化疗治疗高危非肌层浸润性膀胱癌的疗效。方法 收集经尿道膀胱肿瘤电切术术前或术后使用BR-TRG-Ⅱ型体腔热灌注治疗仪行吉西他滨膀胱热灌注化疗治疗高危非肌层浸润性膀胱癌患者40例，其中16例行术前（吉西他滨1000 mg，45℃，45 min）新辅助膀胱热灌注化疗3次，隔天一次，治疗结束后3~7天行经尿道膀胱肿瘤电切术，定义为新辅助组；另外24例患者先行TURBT手术，术后即刻或者隔天（吉西他滨1000 mg，45℃，45 min）行辅助膀胱热灌注化疗，定义为辅助组。记录并比较两组患者无疾病复发生存期（RFS）以及不良反应。结果 全部40例患者均完成3次吉西他滨膀胱热灌注化疗，新辅助组患者中，完全缓解（pT0）11例（68.8%），部分缓解5例（31.2%）。新辅助组中位无复发生存期为54月，辅助组中位无复发生存期为45月，两者比较差异无统计学意义（P=0.3146）。两组患者不良反应可耐受。结论 无论是新辅助还是辅助治疗，使用BR-TRG-Ⅱ型体腔热灌注治疗仪行吉西他滨膀胱热灌注化疗治疗高危非肌层浸润性膀胱癌安全有效
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