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DOI: 10.3971/j.issn.1000-8578.2019.18.1213
Keywords: Advances in Immunotherapy for Malignant Tumors,Pathogenesis of Anti-cancer Drugs-induced Cardiovascular Diseases: The State-of-the-art,Cardiotoxicity and Mechanisms of Immune Checkpoint Inhibitors,Research Progress of CD47-SIRPα Signaling Axis as An Innate Immune Checkpoint in Cancer,Progress of Molecular Imaging-guided Tumor Immunotherapy,Novel Findings on Activation of PD1/PD-L1 that Contributes to Cancer Development and Metastasis,Advances of Tumor Vaccine in Lung Cancer Therapy,Anti-tumor Effect of Dentritic Cells Vaccine Sensitized by GnRH/M2 and mGM-CSF/βhCG Fusion Proteins on Prostatic Cancer in Mice
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摘要 目的 探讨活化早期阶段（脾组织内，未向靶器官迁移的）T细胞程序性死亡受体1（PD-1）表达情况。方法 6~8周龄C57BL/6小鼠随机分组后，以Poly I:C肽疫苗免疫，7天后获取小鼠脾细胞，观察Poly I:C对非特异性及特异性T细胞活化的影响，并检测特异性CD8+T细胞表面PD-1表达。同时，通过敲除CD8细胞观察Poly I:C的抗肿瘤效应是否与CD8+T细胞相关。结果 小鼠经Poly I:C免疫后，脾组织内非特异性及特异性T细胞活化均显著增强；活化的特异性CD8+T细胞虽高表达PD-1，但仍可合成T细胞功能性分子IFN-γ。此外，Poly I:C能显著抑制荷瘤小鼠黑色素瘤生长（P=0.0243），且该效应与CD8+T细胞有关。结论 Poly I:C可以促进T细胞活化；活化早期的（脾组织内）T细胞虽高表达PD-1，但仍具有功能
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