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DOI: 10.3971/j.issn.1000-8578.2019.18.1360
Keywords: A Meta-analysis,Evaluation of 192Ir-Based Hypofractionated Stereotactic Ablative Brachytherapy as A Neoadjuvant Treatment for Operable Peripheral Non-small Cell Lung Cancer,Clinical Observation of Metronomic Oral Vinorelbine Monotherapy as First-line Treatment on Elderly Patients with Advanced Non-small Cell Lung Cancer,Progress of Apatinib in Treatment of Non-small Cell Lung Cancer,Research Progress of Biomarkers for Immunotherapy on Non-small Cell Lung Cancer,Expression of β1,3-N-acetylglucosaminyltransferase-3 in Non-small Cell Lung Cancer and Its Clinical Significance,Antibodies to GABAB Receptor Encephalitis in Small Cell Lung Cancer: A Case Report,Construction of pcDNA3.1-CD74-ROS1 Recombinant Plasmid and Effect of CD74-ROS1 Expression on Proliferation and Migration of Lung Cancer Cells,LncRNA AC009336.24 Expression in Small Cell Lung Cancer and Its Relationship with Chemotherapy Resistance
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摘要 小细胞肺癌（SCLC）约占肺癌的15%，致死率高。SCLC的病理、分子生物学机制和临床预后特征与非小细胞肺癌（NSCLC）不尽相同。大多数SCLC表达神经内分泌特征（整合了神经和内分泌特性），其分子机制可能与TP53和RB1的失活，以及包括Notch信号在内的多个信号通路的频繁中断有关。近年来，随着分子机制研究深入和相关的基因工程小鼠模型的开发以及建立患者来源的异种移植物模型的研究进展，为发现SCLC潜在的治疗靶点，改善疗效和预后带来了新希望
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