环状RNA hsa_circ_0001649在直肠癌中的表达及其临床价值
The expression level of hsa_circ_0001649 incolorectal cancer and its clinical value

摘要：目的 探究环状RNA hsa_circ_0001649在结直肠癌组织中的表达。方法 通过qRT-PCR探究环状RNA hsa_circ_0001649在结直肠癌患者肿瘤血液和组织中的表达。结果 环状RNA hsa_circ_0001649在肿瘤组织中的表达明显低于癌旁组织(P<0.010)，在术后患者的外周血中表达升高，以hsa_circ_0001649在组织中的表达作为指标进行ROC曲线分析，其曲线下面积是0.828。进一步分析发现，环状RNA hsa_circ_0001649的表达程度与肿瘤的分化程度有着密切的关系(P=0.039)。结论 环状RNA hsa_circ_0001649在结直肠癌肿瘤组织中的表达明显降低，对于结直肠癌的诊断有潜在的应用价值。
ABSTRACT: Objective To explore the expression level of hsa_circ_000164 9 in colorectal cancer (CRC). Methods In this experiment, the expression level of hsa_circ_0001649 in CRC tissue was tested by using real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCRs). Results The expression level of hsa_circ_0001649 was obviously down-regulated in CRC tissue, compared with paired paracancerous histological normal tissues (PCHNTs) (P<0.010). Hsa_circ_0001649 was obviously up-regulated in the patients？？ peripheral blood after operation. The area under the receiver operating characteristic (ROC) curve was 0.828. We also found a significant connection between the expression level of hsa_circ_0001649 and pathological differentiation of CRC (P=0.039). Conclusion hsa_circ_0001649 was obviously down-regulated in CRC; therefore, it may be used as a new biomarker in the diagnosis of CRC