利用脑电图功率谱密度研究电针的镇静作用
The sedative effect of electro-acupuncture on healthy people and its possible mechanism using electroencephalogram power spectral density

摘要：目的 采用脑电图功率谱密度(PSD)探讨电针对健康人产生镇静作用的可能机制。方法 对12例健康受试者的双侧足三里、神门、三阴交穴位给予电针刺激，分别记录30min无电针(静息态)及电针(电针态)两种状态下的多通道脑电图(EEG)信号，同时双频谱指数监测仪(BIS)监测被试者的镇静程度。利用PSD分析电针过程中脑电图的功率变化。结果 与静息态相比，电针状态BIS值降低(P<0.05)；脑电信号δ波段功率增加(P<0.05)，α波段功率降低(P<0.05)。结论 电针单独作用可产生镇静作用，电针产生的镇静作用使得脑电活动发生改变，慢波活动增加，推测与其产生的镇静作用相关。
ABSTRACT: Objective To explore the sedative effect of electro-acupuncture on healthy people and its possible mechanism by using EEG power spectral density. Methods Totally 12 healthy subjects were stimulated by electro-acupuncture at bilateral Zusanli (ST36), Shenmen (HT7) and Sanyinjiao (SP6) acupoints. The multichannel EEG signals induced by electro-acupuncture in electroacupuncture-free state (resting state) and electro-acupuncture state were recorded for 30 minutes respectively. The sedation level of the subjects was monitored by bispectral index monitor (BIS). The power spectrum density (PSD) was employed to analyze the power changes of EEG during electro-acupuncture. Results Compared with that of the resting state, the BIS value of electro-acupuncture state decreased significantly (P<0.05), the δ band power of EEG signal increased significantly (P<0.05), the α band power of EEG signal decreased significantly (P<0.05). Conclusion Electro-acupuncture alone can produce sedative effect. The change of EEG activity and the increase of slow wave activity may be related to the sedative effect