CT定量技术在慢性阻塞性肺疾病中的研究现状与展望
Overview and outlook of CT quantification technology for chronic obstructive pulmonary disease

摘要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)患者临床表现具有多样性、异质性强的特点，COPD早期诊断困难，稳定期生活质量差，频繁急性加重的患者住院治疗费用高，属于高社会负担和经济负担疾病。COPD具有患病率、致残率和致死率高的特点，预计到2020年COPD将成为世界第3大死亡病因，也是第5位的主要致残性疾病。目前尚缺乏针对COPD精确全面的定量技术。本研究团队在承担国家卫生健康委员会公益性行业专项“基于数字肺的呼吸系统疾病诊断与评价体系”的基础上，基于CT定量技术，以肺实质、肺支气管、肺血管为3条研究轴线，研究了上述3种肺部组织结构在COPD患者中的形态学变化以及相互之间的联系，对COPD患者进行了个体化、标准化、全方位的评估。此外，本文还对COPD的热点问题进行讨论，指出了下一步的研究方向。
ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a type of disease with diverse clinical manifestations and strong heterogeneity; thus early diagnosis is difficult. Patients at stable period often suffer from poor life quality. Frequent hospitalization induced by acute exacerbations has high social and economic burdens. COPD is predicted to be the third leading cause of death in the world by 2020 and the fifth leading cause of disability. At present, there is a lack of accurate quantitative technology. Our research team, in bearing of the Public Welfare Special Industry of National Health Commission ？？Diagnostic and Evaluation System of Respiratory Diseases Based on Digital Lung？？ and on the basis of CT quantitative technology, investigated the morphological changes of pulmonary parenchyma, bronchi and pulmonary vessels as well as their correlations. We provide an individualized, standardized and comprehensive evaluation for COPD patients. In this paper we also discuss the hot issues of COPD and point out the future research direction