近年来，长非编码RNAs（long non-coding RNAs, lncRNAs) 在肺腺癌发生发展中的作用备受关注。生物信息学预测，长非编码RNA337(LINC00337)在肺腺癌组织中的表达量显著高于其在正常组织中的表达量，且其高表达与患者较差的预后正相关。qRT-PCR结果发现，LINC00337在肺腺癌细胞中的表达量也高于正常肺上皮细胞：LINC00337在肺腺癌细胞H1975和A549中的表达量分别是其在正常肺上皮细胞BEAS-2B中的2.6和10.3倍。在肺腺癌细胞中，上调LINC00337将增加细胞周期蛋白E2 (cyclin E2, CCNE2)的表达，进而促进该细胞增殖；相反，敲低LINC00337将抑制CCNE2的表达，最终阻止肺腺癌细胞增殖。生物信息学预测结合染色质沉淀实验证实，信号转导和活化转录因子1（signal transducer and activator of transcription 1, STAT1）可结合在CCNE2启动子上，下调其表达。在H1975细胞中，过表达STAT1可下调57.76%的CCNE2。在此细胞中，同时过表达STAT1和敲低LINC00337，发现该组细胞的CCNE2表达量增加1.62倍。相反，在A549细胞中敲低STAT1，发现CCNE2可增加6.48倍表达量。但在此细胞中，同时敲低STAT1和过表达LINC00337，则发现该组细胞的CCNE2表达量无变化。上述结果提示，LINC00337对CCNE2的调控需要STAT1的存在。总之，LINC00337通过转录因子STAT1调控CCNE2表达促进肺腺癌细胞增殖
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