The role of 4-pba on tnf-alpha related apoptosis on human vein endothelial cells

Tumor Necrotizing Factor-alpha (TNF-α) has been well-known as a potent pro-inflamatory cytokine involved in many degenerative disease. Oneof its primary target organ-damaged wasendothelial cellswhich willlead to its endoplasmic reticulum stress (ERS) and induced its apoptosis. Endothelial cell apoptosis will lead high implication in many disease pathomechanism ofmany degenerative disease. Some study report ERS inhibitor 4-Phenyl Butyric Acid (4-PBA) properties to inhibitinflammation processin endothelial cells.However, wether 4-PBA can decrease apoptosis level in inflamationof endothelial cells is still poorly understoo