Large Extramedullary Plasmacytoma in Oral Cavity in a patient with Lympho plasmacytic Non-Hodgkin’s Lymphoma

Aims: To report a case of female patient with a rare and large extramedullary plasmacytoma in oral cavity. Methods and Results: This case report refers to a 39-year-old female patient, with a bilateral tissue growth in the region of the lower premolars teeth, presenting reddish color, softened consistency, sessile base and no pain symptomatology. From the clinical data, a diagnostic hypothesis of oral plasmacytoma was reached. The samples collected from the patient underwent histopathological and immunohistochemical analysis for diagnostic purposes. Confirmation of the initial diagnosis of Oral Plasmacytoma was obtained, and bone marrow analysis led the medical team to close a diagnosis of Lymphoplasmacytic Non-Hodgkin’s Lymphoma. The treatment of choice was chemotherapy, using the EPOCH regimen. The oral tumors responded well to the chemotherapy regimen, but the patient died due to the systemic condition. Conclusions: Plasmacytomas are malignant and rare tumors of plasma cells, being poorly diagnosed in the oral cavity region. So, it is emphasized the importance of the Dentist’s awareness for the early diagnosis and correct referral, thus exerting an important role in the identification of oral manifestations resulting from systemic diseases and vice versa. Keywords: Oral Cancer; Hematology; Rare Disorders; Plasmacytom