Influence to Autoimmune Processes of Patients Suffering from Osteoarthritis

In the past few years, it has become more obvious that osteoarthritis (OA) is one of the most widespread chronic disabling diseases. According to different epidemiological reports, nearly 80% of the populations by the age of 60 are suffering from OA. Herewith most of them have some form of movement restriction, and 25% of them are unable to take care of themselves independently in everyday life. It is noted that OA is a problem, which is widespread throughout Ukraine [1, 2]. Lately, great importance in OA diagnostics has been devoted to investigate OA pathogenesis autoimmune components, in particular, that of hyaluronic acid antibodies (HAAB) and collagen antibodies (CAB). Since hyaluronic acid and collagen are the main components of the cartilaginous tissue matrix. The goal of our study is to determine the benefits of magnesium oil for patients suffering from the autoimmune processes of osteoarthritis. Testing was conducted at the rheumatology department of Poltava Regional Clinical Hospital of Sklifosovsky N.V. 30 patients were chosen for this study (11 men, 19 women, with an average age of 61±7 years), who are suffering from OA in the poignant stage. Diagnose was determined by the guidelines of American Rheumatology Association criteria due to the clinical and radiological data complexes of OA. The main first group (I) (consisting of 15 patients) held physiotherapy courses of 10 sessions of electrophoresis in addition to Magnesium Oil application. The second (II) group of 15 patients served as control group. This group was given a course of electrophoresis with “Fastum Gel” applications. According to the given goal special interest was taken in the examination of both HAAB and CAB levels in the blood by immunofluorescence analysis method before therapy began (outgoing data) and in dynamic treatment in the 21 days allotted for this study. In the 21 days the HAAB and CAB levels decreased in both groups but their dynamic make up was different due to the application method (Table 1). Concentration of the HAAB and CAB in the first Group significantly decreased on average to 2,13 ± 0,32 units of optical density and 1,04 ± 0,13 units of optical density in accordance to outgoing data (t = 2,26; р < 0,05 ？ t = 2,29; р < 0,05, accordingly). Another situation was in Group II in the analysis of the HAAB and CAB levels. Within the 21 days of the test the HAAB and CAB levels decreased (2,95 ± 0,21 units of optical density and 1,75 ± 0,22 units of optical density, accordingly), but we haven’t determined statistically significant differences in comparison with