Inflammation and reactive oxygen species generation at the peripheral and coronary atherosclerosis, comparative evaluation of its intensity and grade

The inflammation and oxidative stress are a basis of pathogenesis of an atherosclerosis and vulnerability of the atherosclerotic plaque, triggered by risk factors, including the expression of adhesion molecules, the proliferation and migration of smooth muscle cells, the apoptosis of endothelial cells, the oxidation of lipids, the activation of metalloproteinase and the alteration of vasomotor activity. Heterogeneity of initiation of the system inflammatory answer at an atherosclerosis causes necessity of studying factors of an inflammation and its correlation with traditional metabolic disorders at an atherosclerosis of various localizations