Assay of Hydroxypropoxy Group in Hydroxypropyl Cellulose by United States Pharmacopeia-Titration Method

Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water soluble and organic solubility, used as food additive and sieving matrix for DNA separation. Hydroxypropyl Cellulose is partially substituted poly (hydroxypropyl) ether of cellulose. It contains NLT 53.4% and NMT 80.5% of hydroxypropoxy groups, calculated on the dried basis. It may contain ether suitable anticaking agents, and 0.6 percent of silica (SiO2). The average sample result has been determined 67.3% which was conforms to USP/NF specifications for Hydroxypropyl cellulose