Alzheimer’s disease (AD) is the common cause of
dementia which shows the neuro-pathologies like an accumulation of amyloid-β (Aβ)
and degeneration of cholinergic neuron. Olfactory bulbectomized (OBX) mice show
some of AD features, so they have been used to research as AD model.
Mesenchymal stem cells (MSCs) can differentiate into many kinds of cells,
including neuronal cells. In this study, we intranasally administrated the
conditioned medium derived from cultured umbilical cord (UC) MSCs. The
intranasal administration of the MSCs medium restored the cognitive impairment
observed in OBX mice. In addition, the decreased number of choline
acetyltransferase-positive cells in the medial septum was restored by the
conditioned medium administration. In conclusion, MSCs-derived conditioned
medium may have protective effects of cholinergic neurons in the medial septum,
thereby rescuing the cognitive impairment of OBX.
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