Gelatin-stabilized composites of silver nanoparticles and curcumin: characterization, antibacterial and antioxidant study

ABSTRACT This is a preliminary study of a material comprising gelatin (Gel), silver nanoparticles (AgNPs) and curcumin (Cur) aimed for wound-healing treatment. Gelatin was used to stabilize AgNPs and encapsulate curcumin to form a therapeutic composite (GelCurAg) for their strong bactericidal and antioxidant properties. GelCurAg formulations with different gelatin concentrations were characterized to attain information about their physiochemical properties and the loading efficiency of therapeutic agents. In vitro assessment of GelCurAg focused on antibacterial, antioxidant and cytotoxic aspects. The results suggested that Gel1CurAg (synthesized from 1% gelatin solution) could be utilized as potential therapeutic agents in treating infectious wound owing to its bactericidal and antioxidant effects and low toxicity for clinical uses. GRAPHICAL ABSTRAC