Lignan Glycosides from Urena lobata

Four new lignan glycosides; urenalignosides A–D ( 1– 4), along with 12 known ones ( 5– 16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2– 4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC 50 values in the range of 25.5–98.4 μM (positive control; quercetin; IC 50 = 7.2 ± 0.2 μM). View Full-Tex