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-  2018 

microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish

DOI: 10.3349/ymj.2018.59.1.141

Keywords: microRNA, ototoxicity, regeneration, zebrafish

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Abstract:

microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the present study, we show that the microRNA (miR)-183 cluster is upregulated during hair cell regeneration and that its inhibition reduces hair cell regeneration following neomycin-induced ototoxicity in zebrafish

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