Purkinje Cell Cytoplasmic Antibody (PCA-2)-related Chorea–Dystonia Syndrome

There are several causes of adult-onset chorea, with Huntington’s disease (HD) being the most common. We report a patient who developed a complex movement disorder consisting of chorea and dystonia associated with caudate atrophy on brain magnetic resonance imaging (MRI) because of a paraneoplastic etiology that can be easily confused with HD. He was found to have elevated titers of Purkinje cell cytoplasmic antibody (PCA-2) in the serum and cerebrospinal fluid (CSF)