AB015. The expression and function of coiled-coil domain-containing protein 34 in human bladder carcinoma

Urothelial carcinoma of the bladder is a major cause of morbidity and mortality worldwide. Although localized bladder carcinomas could be managed by surgical resection, the recurrence and progression rates are still high. The therapeutic outcomes for patients with advanced bladder carcinoma who receive radiotherapy or chemotherapy remain unsatisfactory. The absence of more effective therapies for bladder carcinoma requires more research into the underlying molecular mechanisms of its tumorigenesis and the development of new treatment aimed at specific molecular targets. The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. The abnormal expression of the coiled-coil domain containing proteins in nasopharyngeal carcinoma, gastric cancer, prostate cancer, pancreatic cancer, breast cancer, colorectal cancer, has a direct link with the phenotype of tumor cell migration, invasion and metastasis. Coiled-coil domain-containing protein 34 (CCDC34) is a protein-coding and disease related gene, while its biological and clinical significances remain largely unknown. Here, we first reported the oncogenic roles of CCDC34, and investigated its biological functions in bladder carcinogenesis