Immunosuppressant drug tacrolimus induced mitochondrial nephrotoxicity, modified PCNA and Bcl-2 expression attenuated by Ocimum basilicum L. in CD1 mice

DOI: 10.1016/j.toxrep.2018.06.003

Keywords: ABC, Avidin-Biotin- Peroxidase, ANOVA, analysis of variance, BUN, blood urea nitrogen, DNPH, dinitrophenylhydrazine, DPPH, 2,2-Diphenyl-1-picrylhydrazyl, EOBPV, Egyptian Organization for Biological Products and Vaccines, GPx, glutathione peroxidase, GSH, glutathione, H&E, hematoxylin and eosin, H2O2, hydrogenperoxide, IAEC, Institutional Animals Ethics Committee, IC, inhibitory concentration, Ip, intraperitoneal, mLPO, mitochondrial lipid peroxidation, Mn-SOD, Mn-superoxide dismutase, NP-SH, nonprotein thiol, OB, Ocimum basilicum, OPA, orthophosphoric acid, PC, protein carbonyl, PCNA-ir, proliferating cell nuclear antigen immunoreactivity, ROS, reactive oxygen species, TAC, tacroliums Tacrolimus, Nephrotoxicity, PCNA, Bcl-2, Ocimum basilicum

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