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-  2019 

Intraoperative Magnetic Resonance Imaging–Guided Glioma Resections in Awake or Asleep Settings and Feasibility in the Context of a Public Health System

DOI: 10.1016/j.wnsx.2019.100022

Keywords: Awake surgery, Glioma, ioMRI, Neuro-oncology, Survival, Volumetric analysis 5-ALA, 5-Aminolevulinic acid, EOR, Extent of resection, FLAIR, Fluid-attenuated inversion recovery, GBM, Glioblastoma multiforme, GTR, Gross total resection, HGG, High-grade glioma, ioMRI, Intraoperative magnetic resonance imaging, LGG, Low-grade glioma, MAC, Monitored anesthesia care, OS, Overall survival, PFS, Progression-free survival, PR, Partial resection, PS, Performance Status, WHO, World Health Organization

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Abstract:

Despite the most recent surgical aids and tools, surgical removal of infiltrating brain tumors remains a challenge. Unclear margins, edematous areas, and infiltrative behavior are the main causes for failing gross total removals. Also, excessive resection of peri-tumoral tissue often carries risks of damaging the nearby functioning cortical and subcortical structures with an unacceptable decrease in patient's quality of life and postoperative functional status, and the risk of making patients not eligible to adjuvant treatments. Awake surgery and intraoperative magnetic resonance imaging (ioMRI) are among the most effective aids in preventing damage to functional brain while maximizing the extent of resection

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