Asthma, COPD & ACOS: -Omics Approach to Refine Treatable Traits in These Conditions

Overlapping characteristics of asthma and COPD frequently coexist in the same patient and the term ACOS has been applied to these patients. Patients with both fixed airflow obstruction and bronchodilator reversibility or bronchial hyperresponsiveness in addition to those with eosinophilic inflammation, a history of allergic disease, and cigarette smoke exposure have been considered to be part of ACOS. In ECLIPSE, symptoms and exacerbations were higher among ACOS patients than COPD patients, irrespective of their severity of airflow limitation, age, sex, lung function and exacerbation history. In addition, ACOS has been associated with larger number of hospital admissions, and use of health-care resources. Clinical phenotypes of ACOS have been divided into those with asthma (asthma-ACOS) or COPD (COPD-ACOS) prominence