DUO: an innovative multidrug delivery system

The ophthalmic market offers many different medications for numerous eye diseases. Several classes of active ingredients are used to treat ocular pathologies, and often patients are prescribed multiple topical medications. In the case of chronic diseases requiring a long-term treatment (i.e. glaucoma, dry eye syndrome, and chronic conjunctivitis), patients often instill more than one drug. The number of medications and the complexity of therapeutic regimen can be a major hurdle for compliance.1 Two or more different kinds of active principles, and consequently more eye drop dispensers, make the therapeutic regimen complex.2 The poor compliance can significantly affect the therapy success, and is regarded as a major cause of treatment failure in the glaucoma field.2 Besides the patient compliance, multidrug therapy has a significant impact on the exposure to preservatives and on average therapy costs.