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-  2016 

Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections

DOI: 10.1186/s13071-016-1616-0

Keywords: FDA library, Soil-transmitted helminthiasis, Drug sensitivity assay, Trichuris muris, Ancylostoma ceylanicum, Heligmosomoides polygyrus

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Abstract:

Treatment options for infections with soil-transmitted helminths (STH) - Ascaris lumbricoides, Trichuris trichiura and the two hookworm species, Ancylostoma duodenale and Necator americanus - are limited despite their considerable global health burden. The aim of the present study was to test the activity of an openly available FDA library against laboratory models of human intestinal nematode infections

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