Peritoneal Dialysis Fluid and Some of Its Components Potentiate Fibrocyte Differentiation

Long-term PD is associated with an increase in fibrocytes. A) Sections from the peritoneum of patients on short-term and long-term PD were stained with picrosirius red, and the stain was quantified. Bar is 200 μM. * indicates p < 0.05 (t-test). Peritoneal sections from B) short-term and C) long-term PD patients were stained for the indicated markers. All images are representative of biopsy samples from at least 3 different patients of each type. Arrows indicate cells with significant overlap in staining with CD45RO and α-SMA. Bar is 10 μm. PD = peritoneal dialysis; α-SMA = α-smooth muscle actin