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-  2019 

Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway

DOI: 10.7717/peerj.6856

Keywords: Cmah, Aging-related hearing loss, PPAR signaling pathway, Inflammation, miRNAs, Small-molecule drug

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Abstract:

Previous evidence has indicated CMP-Neu5Ac hydroxylase (Cmah) disruption inducesaging-related hearing loss (AHL). However, its function mechanisms remain unclear. This study was to explore the mechanisms of AHL by using microarray analysis in the Cmah deficiency animal model

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