全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

Correction: The population genetics of human disease: The case of recessive, lethal mutations

DOI: 10.1371/journal.pgen.1007499

Full-Text   Cite this paper   Add to My Lib

Abstract:

The authors note that the citation of Wright (1937) and Nei (1968) is incorrect in the “Models of mutation-selection balance” section in Results. Wright (1937) not only showed the equilibrium frequency of a deleterious allele for a population of infinite size (Eq 1) but also derived the full equilibrium frequency distribution of a deleterious allele under a finite effective population size. He also derived the mean (Eq 2) allele frequency of a fully recessive deleterious allele and gave approximations for large and small effective population sizes. Nei (1968) further derived the approximate variance (Eq 3) in allele frequency of a fully recessive mutation by using Wright’s general formula. The authors confirm that this error does not affect the conclusions of the article

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133